Caffeine is known to be toxic in very high quantities. An old, fascinating, science experiment tested, in a very unique way, just how toxic certain chemicals are – including caffeine. The results show the effect of caffeine (and other drugs) on our brains by using an uncommon scientific assay — spider web spinning.
http://www.acsh.org/news/2017/05/19/starbucks-and-spider-webs-11288